Immune activation alters cellular and humoral responses to yellow fever 17D vaccine.

ABSTRACT:

Background

Defining the parameters that modulate vaccine responses in African populations will be imperative to design effective vaccines for protection against HIV, malaria, tuberculosis, and dengue virus infections. This study aimed to evaluate the contribution of the patient-specific immune microenvironment to the response to the licensed yellow fever vaccine 17D (YF-17D) in an African cohort.

Methods

We compared responses to YF-17D in 50 volunteers in Entebbe, Uganda, and 50 volunteers in Lausanne, Switzerland. We measured the CD8+ T cell and B cell responses induced by YF-17D and correlated them with immune parameters analyzed by flow cytometry prior to vaccination.

Results

We showed that YF-17D-induced CD8+ T cell and B cell responses were substantially lower in

SUBMITTER: Muyanja E 

PROVIDER: S-EPMC4071376 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature