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Numerosol A-D, new cembranoid diterpenes from the soft coral Sinularia numerosa.

ABSTRACT: Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 ?M.

SUBMITTER: Tseng YJ 

PROVIDER: S-EPMC4071581 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Numerosol A-D, new cembranoid diterpenes from the soft coral Sinularia numerosa.

Tseng Yen-Ju YJ   Yang Yuan-Chien YC   Wang Shang-Kwei SK   Duh Chang-Yih CY  

Marine drugs 20140603 6

Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 μM. ...[more]

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