Metabolomic tools for secondary metabolite discovery from marine microbial symbionts.

ABSTRACT: Marine invertebrate-associated symbiotic bacteria produce a plethora of novel secondary metabolites which may be structurally unique with interesting pharmacological properties. Selection of strains usually relies on literature searching, genetic screening and bioactivity results, often without considering the chemical novelty and abundance of secondary metabolites being produced by the microorganism until the time-consuming bioassay-guided isolation stages. To fast track the selection process, metabolomic tools were used to aid strain selection by investigating differences in the chemical profiles of 77 bacterial extracts isolated from cold water marine invertebrates from Orkney, Scotland using liquid chromatography-high resolution mass spectrometry (LC-HRMS) and nuclear magnetic resonanc

SUBMITTER: Macintyre L 

PROVIDER: S-EPMC4071584 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature