Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.

ABSTRACT: Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

SUBMITTER: Trousil S 

PROVIDER: S-EPMC4071626 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature