Noradrenergic and GABA B receptor activation differentially modulate inputs to the premotor nucleus RA in zebra finches.

ABSTRACT: Neuromodulators can rapidly modify neural circuits, altering behavior. Songbirds provide an excellent system for studying the role of neuromodulation in modifying circuits that underlie behavior because song learning and production are mediated by a discrete set of interconnected nuclei. We examined the neuromodulatory effects of noradrenergic and GABA B receptor activation on synaptic inputs to the premotor robust nucleus of the arcopallium (RA) in zebra finches using whole cell voltage-clamp recording in vitro. In adults, norepinephrine strongly reduced input from the lateral magnocellular nucleus of the anterior nidopallium (LMAN) but only slightly reduced the input from nucleus HVC (proper name), the excitatory input from axon collaterals of other RA neurons, and input from GABAergic i

SUBMITTER: Sizemore M 

PROVIDER: S-EPMC4071943 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature