A bioinformatics pipeline for the analyses of viral escape dynamics and host immune responses during an infection.

ABSTRACT: Rapidly mutating viruses, such as hepatitis C virus (HCV) and HIV, have adopted evolutionary strategies that allow escape from the host immune response via genomic mutations. Recent advances in high-throughput sequencing are reshaping the field of immuno-virology of viral infections, as these allow fast and cheap generation of genomic data. However, due to the large volumes of data generated, a thorough understanding of the biological and immunological significance of such information is often difficult. This paper proposes a pipeline that allows visualization and statistical analysis of viral mutations that are associated with immune escape. Taking next generation sequencing data from longitudinal analysis of HCV viral genomes during a single HCV infection, along with antigen specific T-c

SUBMITTER: Leung P 

PROVIDER: S-EPMC4072169 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature