Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices.

ABSTRACT:

Background

Emissions from a large peat fire in North Carolina in 2008 were associated with increased hospital admissions for asthma and the rate of heart failure in the exposed population. Peat fires often produce larger amounts of smoke and last longer than forest fires, however few studies have reported on their toxicity. Moreover, reliable alternatives to traditional animal toxicity testing are needed to reduce the number of animals required for hazard identification and risk assessments.

Methods

Size-fractionated particulate matter (PM; ultrafine, fine, and coarse) were obtained from the peat fire while smoldering (ENCF-1) or when nearly extinguished (ENCF-4). Extracted samples were analyzed for chemical constituents and endotoxin content. Female CD-1 mice were exposed v

SUBMITTER: Kim YH 

PROVIDER: S-EPMC4072480 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature