Identification of putative pathogenic SNPs implied in schizophrenia-associated miRNAs.

ABSTRACT:

Background

Schizophrenia is a severe brain disorder, and SNPs (Single nucleotide polymorphism) in schizophrenia-associated miRNAs are believed to be one of the important reasons for dysregulation which might contribute to the altered expression of genes and ultimately result in the disease. Identification of causal SNPs in associated miRNAs may have certain significance in understanding the mechanism of schizophrenia.

Results

For the above purposes, a method based on detection of free energy change is proposed for identification of causal SNPs in schizophrenia-associated miRNAs. A miRNA is firstly segmented, and free energy change is computed after adding an SNP into a segment. The method discovers successfully 6 out of 32 known SNPs and some artificial SNPs could cause sign

SUBMITTER: Sun X 

PROVIDER: S-EPMC4072616 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature