Prediction of membrane transport proteins and their substrate specificities using primary sequence information.

ABSTRACT:

Background

Membrane transport proteins (transporters) move hydrophilic substrates across hydrophobic membranes and play vital roles in most cellular functions. Transporters represent a diverse group of proteins that differ in topology, energy coupling mechanism, and substrate specificity as well as sequence similarity. Among the functional annotations of transporters, information about their transporting substrates is especially important. The experimental identification and characterization of transporters is currently costly and time-consuming. The development of robust bioinformatics-based methods for the prediction of membrane transport proteins and their substrate specificities is therefore an important and urgent task.

Results

Support vector machine (SVM)-based computa

SUBMITTER: Mishra NK 

PROVIDER: S-EPMC4072671 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature