Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish.

ABSTRACT: Tuberculosis is still a major health problem worldwide. Currently it is not known what kind of immune responses lead to successful control and clearance of Mycobacterium tuberculosis. This gap in knowledge is reflected by the inability to develop sufficient diagnostic and therapeutic tools to fight tuberculosis. We have used the Mycobacterium marinum infection model in the adult zebrafish and taken advantage of heterogeneity of zebrafish population to dissect the characteristics of adaptive immune responses, some of which are associated with well-controlled latency or bacterial clearance while others with progressive infection. Differences in T cell responses between subpopulations were measured at the transcriptional level. It was discovered that a high total T cell level was usually asso

SUBMITTER: Hammaren MM 

PROVIDER: S-EPMC4072801 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature