Genetic factors underlying discordance in chromatin accessibility between monozygotic twins.

ABSTRACT:

Background

Open chromatin is implicated in regulatory processes; thus, variations in chromatin structure may contribute to variations in gene expression and other phenotypes. In this work, we perform targeted deep sequencing for open chromatin, and array-based genotyping across the genomes of 72 monozygotic twins to identify genetic factors regulating co-twin discordance in chromatin accessibility.

Results

We show that somatic mutations cause chromatin discordance mainly via the disruption of transcription factor binding sites. Structural changes in DNA due to C:G to A:T transversions are under purifying selection due to a strong impact on chromatin accessibility. We show that CpGs whose methylation is specifically regulated during cellular differentiation appear to be prote

SUBMITTER: Kim K 

PROVIDER: S-EPMC4072931 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature