A shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions.

ABSTRACT:

Background

The earliest recognizable stages of breast neoplasia are lesions that represent a heterogeneous collection of epithelial proliferations currently classified based on morphology. Their role in the development of breast cancer is not well understood but insight into the critical events at this early stage will improve efforts in breast cancer detection and prevention. These microscopic lesions are technically difficult to study so very little is known about their molecular alterations.

Results

To characterize the transcriptional changes of early breast neoplasia, we sequenced 3'- end enriched RNAseq libraries from formalin-fixed paraffin-embedded tissue of early neoplasia samples and matched normal breast and carcinoma samples from 25 patients. We find that gene exp

SUBMITTER: Brunner AL 

PROVIDER: S-EPMC4072957 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature