Hypermethylation in the ZBTB20 gene is associated with major depressive disorder.

ABSTRACT:

Background

Although genetic variation is believed to contribute to an individual's susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease. Epigenetics is increasingly believed to play a major role in the development of common clinical phenotypes, including major depressive disorder.

Results

Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an independent cohort of 356 unrelated case-control individuals. The twins with major depre

SUBMITTER: Davies MN 

PROVIDER: S-EPMC4072999 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature