Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model.

ABSTRACT: Studying macrophage biology in the context of a whole living organism provides unique possibilities to understand the contribution of this extremely dynamic cell subset in the reaction to infections, and has revealed the relevance of cellular and molecular processes that are fundamental to the cell-mediated innate immune response. In particular, various recently established zebrafish infectious disease models are contributing substantially to our understanding of the mechanisms by which different pathogens interact with macrophages and evade host innate immunity. Transgenic zebrafish lines with fluorescently labeled macrophages and other leukocyte populations enable non-invasive imaging at the optically transparent early life stages. Furthermore, there is a continuously expanding availabil

SUBMITTER: Torraca V 

PROVIDER: S-EPMC4073269 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature