Cost-effectiveness of the children's oncology group long-term follow-up screening guidelines for childhood cancer survivors at risk for treatment-related heart failure.

ABSTRACT:

Background

Childhood cancer survivors treated with anthracyclines are at high risk for asymptomatic left ventricular dysfunction (ALVD), subsequent heart failure, and death. The consensus-based Children's Oncology Group (COG) Long-Term Follow-up Guidelines recommend lifetime echocardiographic screening for ALVD.

Objective

To evaluate the efficacy and cost-effectiveness of the COG guidelines and to identify more cost-effective screening strategies.

Design

Simulation of life histories using Markov health states.

Data sources

Childhood Cancer Survivor Study; published literature.

Target population

Childhood cancer survivors.

Time horizon

Lifetime.

Perspective

Societal.

Intervention

Echocardiographic screening followed by angiotensin-con

SUBMITTER: Wong FL 

PROVIDER: S-EPMC4073480 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature