Evidence of extensive DNA transfer between bacteroidales species within the human gut.

ABSTRACT:

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The genome sequences of intestinal Bacteroidales strains reveal evidence of extensive horizontal gene transfer. In vitro studies of Bacteroides and other bacteria have addressed mechanisms of conjugative transfer and some phenotypic outcomes of these DNA acquisitions in the recipient, such as the acquisition of antibiotic resistance. However, few studies have addressed the horizontal transfer of genetic elements between bacterial species coresident in natural microbial communities, especially microbial ecosystems of humans. Here, we examine the genomes of Bacteroidales species from two human adults to identify genetic elements that were likely transferred among these Bacteroidales while they were coresident in the intestine. Using seven coresident Bacteroidales species f

SUBMITTER: Coyne MJ 

PROVIDER: S-EPMC4073490 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature