Relationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer.

ABSTRACT:

Purpose

Previous studies of breast tissue gene expression have shown that the extratumoral microenvironment has substantial variability across individuals, some of which can be attributed to epidemiologic factors. To evaluate how mammographic density and breast tissue composition relate to extratumoral microenvironment gene expression, we used data on 121 patients with breast cancer from the population-based Polish Women's Breast Cancer Study.

Experimental design

Breast cancer cases were classified on the basis of a previously reported, biologically defined extratumoral gene expression signature with two subtypes: an Active subtype, which is associated with high expression of genes related to fibrosis and wound response, and an Inactive subtype, which has high expression of

SUBMITTER: Sun X 

PROVIDER: S-EPMC4073678 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature