Detecting overlapping protein complexes based on a generative model with functional and topological properties.

ABSTRACT:

Background

Identification of protein complexes can help us get a better understanding of cellular mechanism. With the increasing availability of large-scale protein-protein interaction (PPI) data, numerous computational approaches have been proposed to detect complexes from the PPI networks. However, most of the current approaches do not consider overlaps among complexes or functional annotation information of individual proteins. Therefore, they might not be able to reflect the biological reality faithfully or make full use of the available domain-specific knowledge.

Results

In this paper, we develop a Generative Model with Functional and Topological Properties (GMFTP) to describe the generative processes of the PPI network and the functional profile. The model provides a w

SUBMITTER: Zhang XF 

PROVIDER: S-EPMC4073817 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature