Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection.

ABSTRACT: Vitamin D has long been linked to resistance to tuberculosis, an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces macrophage antimicrobial functions against Mycobacterium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated transcriptome and mechanistic studies. Transcriptome analysis revealed an association between vitamin D receptor (VDR) and lipid metabolism in human tuberculosis and infected macrophages. Vitamin D treatment of infected macrophages abrogated infection-induced accumulation of lipid droplets, which are required for intracellular M. tuberculosis growth. Additional transcriptomics results showed that vitam

SUBMITTER: Salamon H 

PROVIDER: S-EPMC4073889 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature