Meta-analysis of randomized controlled trials comparing EX-PRESS implantation with trabeculectomy for open-angle glaucoma.

ABSTRACT:

Purpose

To evaluate the efficacy and safety of EX-PRESS implantation compared with trabeculectomy for uncontrolled open-angle glaucoma.

Methods

Pertinent randomized controlled trials were identified through systematic searches of the PubMed, EMBASE, and Cochrane Library. The efficacy measures utilized were the weighted mean differences (WMDs) for the intraocular pressure reduction (IOPR), the reduction in glaucoma medications, the change of visual acuity, and the relative risks (RRs) for operative success rates. The safety measures utilized were RRs for postoperative complications. The pooled effects were calculated using the random-effects model.

Results

Four randomized controlled trials of 292 eyes were included in this meta-analysis. The WMDs of the IOPR comparing

SUBMITTER: Wang W 

PROVIDER: S-EPMC4074054 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature