Hepatitis C virus infection increases risk of developing end-stage renal disease using competing risk analysis.

ABSTRACT:

Background

Chronic kidney disease (CKD) and hepatitis C virus (HCV) infection are closely linked and both increase patient mortality. The association of HCV and risk of developing end-stage renal disease (ESRD) has not been analyzed with competing risk model.

Method

We enrolled a prospective cohort of 4,185 patients (mean age, 62 years; 41% female) registered in the CKD integrated care program at two affiliated hospitals of Kaohsiung Medical University in Taiwan between November 11, 2002 and May 31, 2009. With competing risk model, we analyzed the association of HCV infection, defined by seropositive of anti-HCV antibody, and hepatitis B virus (HBV) infection, defined by seropositive of HBV surface antigen, with the risk of entering ESRD.

Results

The prevalence of HCV

SUBMITTER: Lee JJ 

PROVIDER: S-EPMC4074067 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature