Primary vs. secondary antibody deficiency: clinical features and infection outcomes of immunoglobulin replacement.

ABSTRACT: Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients with primary or secondary antibody deficiencies on immunoglobulin (Ig)-replacement treatment. The demographics, causes of immunodeficiency, diagnostic delay, clinical and laboratory features, and infection frequency were analysed retrospectively. Chemotherapy for B cell lymphoma and the use of Rituximab, corticosteroids or immunosuppressive medications were the most common causes of secondary antibody deficiency in this cohort. There was no difference in diagnostic delay or bronchiectasis between primary and secondary antibody deficiency p

SUBMITTER: Duraisingham SS 

PROVIDER: S-EPMC4074074 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature