Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.

ABSTRACT: Chlamydia trachomatis infections represent the leading cause of bacterial sexually-transmitted disease in the United States and can cause serious tissue damage leading to infertility and ectopic pregnancies in women. Inflammation and hence the innate immune response to chlamydial infection contributes significantly to tissue damage, particularly by secreting proinflammatory cytokines such as interleukin (IL)-1beta from monocytes, macrophages and dendritic cells. Here we demonstrate that C. trachomatis or Chlamydia muridarum infection of a monocytic cell line leads to caspase-1 activation and IL-1beta secretion through a process requiring the NLRP3 inflammasome. Thus, secretion of IL-1beta decreased significantly when cells were depleted of NLRP3 or treated with the anti-inflammatory inhibi

SUBMITTER: Abdul-Sater AA 

PROVIDER: S-EPMC4074088 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature