Interaction networks of prion, prionogenic and prion-like proteins in budding yeast, and their role in gene regulation.

ABSTRACT: Prions are transmissible, propagating alternative states of proteins. Prions in budding yeast propagate heritable phenotypes and can function in large-scale gene regulation, or in some cases occur as diseases of yeast. Other 'prionogenic' proteins are likely prions that have been determined experimentally to form amyloid in vivo, and to have prion-like domains that are able to propagate heritable states. Furthermore, there are over 300 additional 'prion-like' yeast proteins that have similar amino-acid composition to prions (primarily a bias for asparagines and glutamines). Here, we examine the protein functional and interaction networks that involve prion, prionogenic and prion-like proteins. Set against a marked overall preference for N/Q-rich prion-like proteins not to interact with eac

SUBMITTER: Harbi D 

PROVIDER: S-EPMC4074094 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature