Yes-associated protein (YAP) modulates oncogenic features and radiation sensitivity in endometrial cancer.

ABSTRACT:

Background

Yes-associated protein (YAP) is a transcriptional co-activator and regulates cell proliferation and apoptosis. We investigated the clinical and biological significance of YAP in endometrial cancer (EMCA).

Methods

YAP expression in 150 primary tumor tissues from patients with EMCA was evaluated by immunohistochemistry and its association with clinicopathological data was assessed. The biological functions of YAP were determined in EMCA cell lines through knockdown/overexpression of YAP. The role of YAP in modulating radiation sensitivity was also investigated in EMCA cells.

Results

Increased nuclear YAP expression was significantly associated with higher grade, stage, lympho-vascular space invasion, postoperative recurrence/metastasis and overall survival in

SUBMITTER: Tsujiura M 

PROVIDER: S-EPMC4074125 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature