Risk of HIV acquisition among circumcised and uncircumcised young men with penile human papillomavirus infection.

ABSTRACT:

Objectives

There are very few data from men on the risk of HIV acquisition associated with penile human papillomavirus (HPV) infection and no data on the potential modifying effect of male circumcision. Therefore, this study evaluated whether HPV is independently associated with risk of HIV.

Design

A cohort study of HPV natural history nested within a randomized control trial of male circumcision to reduce HIV incidence in Kisumu, Kenya.

Methods

Prospective data from 2519 men were analyzed using 6-month discrete-time Cox models to determine if HIV acquisition was higher among circumcised or uncircumcised men with HPV compared to HPV-uninfected men.

Results

Risk of HIV acquisition was nonsignificantly increased among men with any HPV [adjusted hazard ratio (aHR)

SUBMITTER: Rositch AF 

PROVIDER: S-EPMC4074250 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature