The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging.

ABSTRACT:

Background

The biological basis for sex differences in brain function and disease susceptibility is poorly understood. Examining the role of gonadal hormones in brain sexual differentiation may provide important information about sex differences in neural health and development. Permanent masculinization of brain structure, function, and disease is induced by testosterone prenatally in males, but the possible mediation of these effects by long-term changes in the epigenome is poorly understood.

Methods

We investigated the organizational effects of testosterone on the DNA methylome and transcriptome in two sexually dimorphic forebrain regions-the bed nucleus of the stria terminalis/preoptic area and the striatum. To study the contribution of testosterone to both the establish

SUBMITTER: Ghahramani NM 

PROVIDER: S-EPMC4074311 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature