Ontology highlight
ABSTRACT:
SUBMITTER: Yang SH
PROVIDER: S-EPMC4074343 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Yang Shen-Hsi SH Kalkan Tüzer T Morissroe Claire C Marks Hendrik H Stunnenberg Hendrik H Smith Austin A Sharrocks Andrew D AD
Cell reports 20140612 6
Embryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into all of the cell types in the body. We know a lot about the complex transcriptional control circuits that maintain the naive pluripotent state under self-renewing conditions but comparatively less about how cells exit from this state in response to differentiation stimuli. Here, we examined the role of Otx2 in this process in mouse ESCs and demonstrate that it plays a leading role in remodeling the gene re ...[more]