Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress.

ABSTRACT: The cognitive effects of stress are profound, yet it is unknown if the consequences of concurrent multiple stresses on learning and memory differ from those of a single stress of equal intensity and duration. We compared the effects on hippocampus-dependent memory of concurrent, hours-long light, loud noise, jostling and restraint (multimodal stress) with those of restraint or of loud noise alone. We then examined if differences in memory impairment following these two stress types might derive from their differential impact on hippocampal synapses, distinguishing dorsal and ventral hippocampus. Mice exposed to hours-long restraint or loud noise were modestly or minimally impaired in novel object recognition, whereas similar-duration multimodal stress provoked severe deficits. Differences

SUBMITTER: Maras PM 

PROVIDER: S-EPMC4074447 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature