Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer.

ABSTRACT:

Purpose

This study explored the relationships between variations in cytokines genes and depressive symptoms in a sample of patients who were assessed prior to and for six months following breast cancer surgery. Phenotypic differences between Resilient (n = 155) and Subsyndromal (n = 180) depressive symptom classes, as well as variations in cytokine genes were evaluated.

Method

Patients were recruited prior to surgery and followed for six months. Growth mixture modeling was used to identify distinct latent classes based on Center for Epidemiological Studies Depression (CES-D) Scale scores. Eighty-two single nucleotide polymorphisms and 35 haplotypes among 15 candidate cytokine genes were evaluated.

Results

Patients in the Subsyndromal class were significantly younger,

SUBMITTER: Saad S 

PROVIDER: S-EPMC4074554 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature