Tubal ligation, hysterectomy, unilateral oophorectomy, and risk of ovarian cancer in the Nurses' Health Studies.

ABSTRACT:

Objective

To prospectively examine whether the association between tubal ligation, hysterectomy, unilateral oophorectomy, and ovarian cancer varied by patient, tumor, and surgical characteristics.

Design

Two prospective cohort studies (Nurses' Health Study and Nurses' Health Study II).

Setting

Not applicable.

Patient(s)

A cohort of 121,700 married US female nurses, aged 30-55 years at baseline and another cohort of 116,430 US female nurses aged 25-42 years at baseline.

Intervention(s)

We obtained data on gynecologic surgeries and ovarian cancer incidence through biennial questionnaires. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for known and suspected ovarian cancer risk factors.

Main outcome measure(s)

Confirme

SUBMITTER: Rice MS 

PROVIDER: S-EPMC4074555 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature