Dataset Information

Family history of hypertension and the risk of overweight in Japanese children: results from the Toyama Birth Cohort Study.

ABSTRACT:

Background

Family history can be a useful screening tool in the assessment and management of the risk for noncommunicable disease. However, no data have yet been reported on family history of hypertension and its effect on children's overweight.

Methods

A total of 7249 Japanese children enrolled in the Toyama Birth Cohort Study were followed until 2002 (mean age: 12.3 years). Family history of hypertension was ascertained by asking children's parents whether children's biological parents or grandparents had doctor-diagnosed hypertension. Child overweight was defined according to international criteria for age- and sex-specific body mass index.

Results

The prevalence of child overweight at age 12 was 21.7% for males and 15.9% for females. After adjusting for family structure, parental employment status, and lifestyle factors, we found that a maternal family history of hypertension was positively associated with the risk of child overweight at age 12 (adjusted odds ratio [OR] 1.21, 95% confidence interval [CI] 1.04-1.39). The adjusted OR increased from 1.16 (95% CI 0.99-1.35) to 1.42 (95% CI 1.04-1.92) to 4.75 (95% CI 1.35-16.69) as the number of family members with hypertension increased from 1 to 2 to 3, respectively. There was no significant difference in the prevalence of overweight between children with a paternal family history of hypertension and those without.

Conclusions

A maternal family history of hypertension was positively associated with the risk of overweight in children at age 12.

SUBMITTER: Liu J

PROVIDER: S-EPMC4074635 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Family history of hypertension and the risk of overweight in Japanese children: results from the Toyama Birth Cohort Study.

Liu Jufen J Sekine Michikazu M Tatsuse Takashi T Hamanishi Shimako S Fujimura Yuko Y Zheng Xiaoying X

Journal of epidemiology 20140524 4

<h4>Background</h4>Family history can be a useful screening tool in the assessment and management of the risk for noncommunicable disease. However, no data have yet been reported on family history of hypertension and its effect on children's overweight.<h4>Methods</h4>A total of 7249 Japanese children enrolled in the Toyama Birth Cohort Study were followed until 2002 (mean age: 12.3 years). Family history of hypertension was ascertained by asking children's parents whether children's biological ...[more]

PMID: 24857956

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Project description:All subjects were recruited at Centennial Women?s Hospital and the Perinatal Research Center in Nashville, TN beginning in 2003. Pregnant women were enrolled during their first clinical visit after obtaining informed consent as described previously. Demographic and clinical data specific to the fetus was collected from clinical records. Gestational age of the neonate was determined by maternal reporting of the last menstrual period and corroboration by ultrasound dating. Accurate knowledge of gestational age (GA) is essential for proper monitoring and care of neonates. However, accurate GA measures are often not available. DNA methylation has previously been shown to associate with GA, and has been used to accurately predict chronological age in adults. In the current study, we examine whether DNA methylation in cord blood can be used to predict gestational age at birth. Results: We found that GA can be accurately predicted from DNA methylation of neonatal cord blood and blood spot samples (DNAm GA), using 148 CpG sites selected through elastic net regression in six training datasets (N=207). We evaluated predictive accuracy in six testing datasets (N=1,202), and found that the accuracy of DNAm GA meets or exceeds accuracy of gestational age estimates based on established methods. We also found an increased DNAm GA, relative to clinical GA, was associated with increased birthweight percentile (p=.00057), adjusting for GA, sex, and ancestry, suggesting that DNAm GA could represent developmental age more accurately than clinical estimates of GA. Conclusions: Further development of this predictor could provide a method of accurate neonatal estimation of GA for use in resource-limited populations, or in cases where GA cannot be estimated clinically. When clinical estimates are available, the predictor can be used to test hypotheses related to developmental age and other early life circumstances, and may provide increased accuracy beyond clinical estimates.

Dataset Information

Family history of hypertension and the risk of overweight in Japanese children: results from the Toyama Birth Cohort Study.

Background

Methods

Results

Conclusions

Publications

Family history of hypertension and the risk of overweight in Japanese children: results from the Toyama Birth Cohort Study.

Similar Datasets

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