The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Studies suggest that the 9p21-3 locus may influence susceptibility to myocardial infarction. We performed a systematic review and meta-analysis to assess whether this locus is associated with severity of coronary atherosclerosis and adverse clinical outcomes in those with known coronary disease.

Methods

Multiple electronic databases were searched from inception through August 2012. Studies examining 9p21-3 genotype in patients with known coronary artery disease were included. We extracted the association of the 9p21-3 locus with measures of severity of coronary atherosclerosis [number of diseased vessels, Gensini Score, Duke CAD Prognostic Index (DPI)], angiographic outcomes [change in minimum lumen diameter (∆MLD) and number of new lesions at follow-up], and key

SUBMITTER: Munir MS 

PROVIDER: S-EPMC4074865 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature