Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

ABSTRACT: Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.

SUBMITTER: Mazzone JR 

PROVIDER: S-EPMC4074917 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature