Health-related quality of life in patients with autosomal dominant polycystic kidney disease and CKD stages 1-4: a cross-sectional study.

ABSTRACT:

Background

In people with early autosomal dominant polycystic kidney disease (ADPKD), average total kidney volume (TKV) is 3 times normal and increases by an average of 5% per year despite a seemingly normal glomerular filtration rate (GFR). We hypothesized that increased TKV would be a source of morbidity and diminished quality of life that would be worse in patients with more advanced disease.

Study design

Cross-sectional.

Setting & participants

1,043 patients with ADPKD, hypertension, and a baseline estimated GFR (eGFR)> 20mL/min/1.73m(2).

Predictors

(1) eGFR, (2) height-adjusted TKV (htTKV) in patients with eGFR> 60mL/min/1.73m(2).

Outcomes

36-Item Short Form Health Survey (SF-36) and the Wisconsin Brief Pain Survey.

Measurements

Questionnaire

SUBMITTER: Miskulin DC 

PROVIDER: S-EPMC4075014 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature