MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation.

ABSTRACT: Although cervical pregnancy and placenta previa, in which the embryo and placenta embed in or adjacent to the cervix, are life-threatening complications that result in massive bleeding and poor pregnancy outcomes in women, the incidence of these aberrant conditions is uncommon. We hypothesized that a local molecular mechanism is normally in place to prevent embryo implantation in the cervix. The ovarian hormones progesterone (P(4)) and estrogen differentially direct differentiation and proliferation of endometrial cells, which confers the receptive state for implantation: P(4) dominance causes differentiation of the luminal epithelium but increases stromal cell proliferation in preparation of the uterus for implantation. In search for the cause of cervical nonresponsiveness to implantation

SUBMITTER: Haraguchi H 

PROVIDER: S-EPMC4075165 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature