Genome-wide Association Studies for Osteoporosis: A 2013 Update.

ABSTRACT: In the past few years, the bone field has witnessed great advances in genome-wide association studies (GWASs) of osteoporosis, with a number of promising genes identified. In particular, meta-analysis of GWASs, aimed at increasing the power of studies by combining the results from different study populations, have led to the identification of novel associations that would not otherwise have been identified in individual GWASs. Recently, the first whole genome sequencing study for osteoporosis and fractures was published, reporting a novel rare nonsense mutation. This review summarizes the important and representative findings published by December 2013. Comments are made on the notable findings and representative studies for their potential influence and implications on our present underst

SUBMITTER: Liu YJ 

PROVIDER: S-EPMC4075273 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature