Using functional signature ontology (FUSION) to identify mechanisms of action for natural products.

ABSTRACT: A challenge for biomedical research is the development of pharmaceuticals that appropriately target disease mechanisms. Natural products can be a rich source of bioactive chemicals for medicinal applications but can act through unknown mechanisms and can be difficult to produce or obtain. To address these challenges, we developed a new marine-derived, renewable natural products resource and a method for linking bioactive derivatives of this library to the proteins and biological processes that they target in cells. We used cell-based screening and computational analysis to match gene expression signatures produced by natural products to those produced by small interfering RNA (siRNA) and synthetic microRNA (miRNA) libraries. With this strategy, we matched proteins and miRNAs with diverse b

SUBMITTER: Potts MB 

PROVIDER: S-EPMC4075427 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature