Ontology highlight
ABSTRACT:
SUBMITTER: de Almeida PE
PROVIDER: S-EPMC4075468 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Nature communications 20140530
The exact nature of the immune response elicited by autologous-induced pluripotent stem cell (iPSC) progeny is still not well understood. Here we show in murine models that autologous iPSC-derived endothelial cells (iECs) elicit an immune response that resembles the one against a comparable somatic cell, the aortic endothelial cell (AEC). These cells exhibit long-term survival in vivo and prompt a tolerogenic immune response characterized by elevated IL-10 expression. In contrast, undifferentiat ...[more]