Mitochondrial proteome remodeling in ischemic heart failure.

ABSTRACT:

Aims

Mitochondrial dysfunction is an important part of the decline in cardiac function in heart failure. We hypothesized for hypothesized that there would be specific abnormalities in mitochondrial function and proteome with the progression of ischemic heart failure (HF).

Main methods

We used a high left anterior descending artery (LAD) ligation in 3-4month old male rats to generate HF. Rats were studied 9weeks post-ligation.

Key findings

Electron microscopy of left ventricle samples showed mitochondrial changes including decreased size, increased number, abnormal distribution, and cristae loss. Mitochondria in ischemic HF exhibited decreased total ATP, impaired mitochondrial respiration, as well as reduced complex I activity. Analysis of LV mitochondrial proteins by

SUBMITTER: Liu T 

PROVIDER: S-EPMC4075482 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature