Uric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients.

ABSTRACT:

Background

In patients with chronic kidney disease (CKD) hyperuricemia is common. Evidence that hyperuricemia might also play a causal role in vascular disease, hypertension and progression of CKD is accumulating. Therefore, we studied the association between baseline uric acid (UA) levels and the rate of decline in renal function and time until start of dialysis in pre-dialysis patients.

Methods

Data from the PREPARE-2 study were used. The PREPARE-2 study is an observational prospective cohort study including incident pre-dialysis patients with CKD stages IV-V in the years between 2004 and 2011. Patients were followed for a median of 14.9 months until start of dialysis, kidney transplantation, death, or censoring. Main outcomes were the change in the rate of decline in rena

SUBMITTER: Nacak H 

PROVIDER: S-EPMC4075499 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature