MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury.

ABSTRACT:

Study design

Experimental, controlled, animal study.

Objectives

To use non-invasive magnetic resonance imaging (MRI) to corroborate invasive studies showing progressive expansion of a hemorrhagic lesion during the early hours after spinal cord trauma and to assess the effect of glibenclamide, which blocks Sur1-Trpm4 channels implicated in post-traumatic capillary fragmentation, on lesion expansion.

Setting

Baltimore.

Methods

Adult female Long-Evans rats underwent unilateral impact trauma to the spinal cord at C7, which produced ipsilateral but not contralateral primary hemorrhage. In series 1 (six control rats and six administered glibenclamide), hemorrhagic lesion expansion was characterized using MRI at 1 and 24 h after trauma. In series 2, hemorrhagic lesion

SUBMITTER: Simard JM 

PROVIDER: S-EPMC4076111 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature