Allelic imbalance in the miR-31 host gene locus in lung cancer--its potential role in carcinogenesis.

ABSTRACT: Small non-protein coding RNA, microRNA (miR), which regulate messenger RNA levels, have recently been identified, and may play important roles in the pathogenesis of various diseases. The present study focused on miR-31 and investigated its potential involvement in lung carcinogenesis. The expression of miR-31 was altered in lung cancer cells through either the amplification or loss of the host gene locus. The strong expression of miR-31 in large cell carcinomas was attributed to the gene amplification. Meanwhile, the loss of miR-31 expression was more frequently observed in aggressive adenocarcinomas. Thus, miR-31 may play a pleiotropic role in the development of lung cancers among different histological types. To the best of our knowledge, this is the first study to show the potential ca

SUBMITTER: Okudela K 

PROVIDER: S-EPMC4076198 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature