Building a hierarchical organization of protein complexes out of protein association data.

ABSTRACT: Organizing experimentally determined protein associations as a hierarchy can be a good approach to elucidating the content of protein complexes and the modularity of subcomplexes. Several challenges exist. First, intrinsically sticky proteins, such as chaperones, are often falsely assigned to many functionally unrelated complexes. Second, the reported collections of proteins may not be true "complexes" in the sense that they bind together and perform a joint cellular function. Third, due to imperfect sensitivity of protein detection methods, both false positive and false negative assignments of a protein to complexes may occur. We mitigate the first issue by down-weighting sticky proteins by their occurrence frequencies. We approach the other two problems by merging nearly identical comple

SUBMITTER: Stojmirovic A 

PROVIDER: S-EPMC4076247 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature