A comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosa.

ABSTRACT:

Objective

Sexual transmission of HIV occurs across a mucosal surface, which contains many soluble immune factors important for HIV immunity. Although the composition of mucosal fluids in the vaginal and oral compartments has been studied extensively, the knowledge of the expression of these factors in the rectal mucosa has been understudied and is very limited. This has particular relevance given that the highest rates of HIV acquisition occur via the rectal tract. To further our understanding of rectal mucosa, this study uses a proteomics approach to characterize immune factor components of rectal fluid, using saliva as a comparison, and evaluates its antiviral activity against HIV.

Methods

Paired salivary fluid (n = 10) and rectal lavage fluid (n = 10) samples were collect

SUBMITTER: Romas LM 

PROVIDER: S-EPMC4076261 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature