Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.

ABSTRACT: Menopause is the permanent cessation of menstruation that results from depletion of ovarian germ cells and follicles. Although most animals experience reproductive senescence, the mechanisms differ from that in women, who may live more than one-third of their lives after menopause and consequently face the risk of a number of menopause-associated health problems. Understanding factors that influence ovarian aging may provide strategies to delay or alleviate physiological alterations that take place in postmenopausal women. The germ cell-deficient Wv mice recapitulate follicle loss, prolong postreproductive lifespan, and model many physiological changes that take place in postmenopausal women. Here, using genetic and pharmacological approaches, we found that inhibition of cyclooxygenase-1 b

SUBMITTER: Smith ER 

PROVIDER: S-EPMC4076395 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature