Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth.

ABSTRACT: Assisted reproductive technologies (ART) have been associated with several adverse perinatal outcomes involving placentation and fetal growth. It is critical to examine each intervention individually in order to assess its relationship to the described adverse perinatal outcomes. One intervention ubiquitously used in ART is superovulation with gonadotropins. Superovulation results in significant changes in the hormonal milieu, which persist during the peri-implantation and early placentation periods. Epidemiologic evidence suggests that the treatment-induced peri-implantation maternal environment plays a critical role in perinatal outcomes. In this study, using the mouse model, we have isolated the exposure to the peri-implantation period, and we examine the effect of superovulation on pla

SUBMITTER: Mainigi MA 

PROVIDER: S-EPMC4076405 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature