The impact of image smoothness on intrinsic functional connectivity and head motion confounds.

ABSTRACT: We present a novel method for controlling the effects of group differences in motion on functional connectivity studies. Resting-state functional magnetic resonance imaging (rs-fMRI) is a powerful tool that allows for the assessment of whole-brain functional organization across a wide range of clinical populations. However, as highlighted by recent studies, many measures commonly used in rs-fMRI are highly correlated with subject head movement. A source of this problem is that motion itself, and motion correction algorithms, lead to spatial smoothing, which is then variable across the brain and across subjects or groups dependent upon the amount of motion present during scanning. Studies aimed at elucidating differences between populations that have different head-motion characteristics (e

SUBMITTER: Scheinost D 

PROVIDER: S-EPMC4076413 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature