Association of glutathione peroxidase-1 (GPx-1) rs1050450 Pro198Leu and Pro197Leu polymorphisms with cardiovascular risk: a meta-analysis of observational studies.

ABSTRACT:

Objective

To clarify the association between rs1050450 polymorphism in Glutathione peroxidase-1 (GPx-1) and the risk of cardiovascular diseases (CVD) by performing a meta-analysis of published studies. There is growing evidence from different study types for an association of the GPx-1 polymorphism and cardiovascular outcomes, but observational studies have so far shown inconsistent results.

Methods

Relevant publications were searched through PubMed, Embase database databases and the Cochrane Library. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of association under the best genetic model. Both Q statistic and the I (2) were used to check heterogeneity. Meta-regression analysis was performed to explore heterogeneity source. Sensitivity

SUBMITTER: Zhang JX 

PROVIDER: S-EPMC4076455 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature