Characterization, design, and function of the mitochondrial proteome: from organs to organisms.

ABSTRACT: Mitochondria are a common energy source for organs and organisms; their diverse functions are specialized according to the unique phenotypes of their hosting environment. Perturbation of mitochondrial homeostasis accompanies significant pathological phenotypes. However, the connections between mitochondrial proteome properties and function remain to be experimentally established on a systematic level. This uncertainty impedes the contextualization and translation of proteomic data to the molecular derivations of mitochondrial diseases. We present a collection of mitochondrial features and functions from four model systems, including two cardiac mitochondrial proteomes from distinct genomes (human and mouse), two unique organ mitochondrial proteomes from identical genetic codons (mouse hear

SUBMITTER: Lotz C 

PROVIDER: S-EPMC4076470 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature